Tumour-localising and -photosensitizing properties of liposome-delivered Ge(IV)-octabutoxy-phthalocyanine
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چکیده
منابع مشابه
Tumour-localizing and tumour-photosensitizing properties of zinc(II)-octapentyl-phthalocyanine.
Zn(II)-octapentyl-phthalocyanine (ZnOPPc), incorporated into a Cremophor oil emulsion, was found to be a highly selective tumour-targeting agent (50-fold larger concentration in the tumour than in the peritumoral tissue) when injected at a dose of 1.46 mumol (kg body weight)-1 in Balb/c mice bearing an intramuscularly transplanted MS-2 fibrosarcoma. The pharmacokinetic properties of this phthal...
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in this article, we describe a photosensitizer (ps) whose ability to generate singlet oxygen (1o2) and fluorescence emission has been designed as tumor responsive. more specifically, the ps consists of a silicon phthalocyanine (sipc) core, axially substituted with two subphthalocyanine (subpc) units, covalently linked by a disulfide linker, which is cleavable in the presence of a strong reducin...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1991
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1991.247